Growth rate of mammary cancers arising in irradiated mice is associated with pattern of immune infiltrate. Growth rate of mammary cancers arising in irradiated mice is associated with pattern of immune infiltrate

To determine how host irradiation affects tumor profiles in 10 month aged mice treated with HZE or gamma irradiation. Overall design: Total RNA was extracted from mammary tumors derived from transplantations of non-irradiated p53 null mammary fragments into irradiated hosts. We analyzed 43 tumors from 10-month aged whole body irradiated hosts with (1) sham n = 10, 50, 100 cGy γ-ray sparsely ionizing radiation (SIR) n = 15, or at equivalent fluences of 350 Mev/amu Ar, 350 Mev/amu Si or 600 Mev Fe densely ionzing radiation (DIR) n = 19