Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid

Protein Data Bank Japan2023-09-27 更新2026-03-21 收录

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Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid Descriptor: (1S,2R,3S,4R,5S)-5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ... Authors: Chattopadhyay, D, Swingle, M.R, Salter, E.A, Wierzbicki, A, Honkanen, R.E. Deposit date: 2015-05-19 Release date: 2016-04-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.23 Å) Cite: Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochem. Pharmacol., 109, 2016

PP5与5-甲基-7-氧杂双环[2.2.1]庚烷-2,3-二羧酸的共晶体结构。描述项：(1S,2R,3S,4R,5S)-5-甲基-7-氧杂双环[2.2.1]庚烷-2,3-二羧酸、(4R)-2-甲基戊烷-2,4-二醇、(4S)-2-甲基-2,4-戊二醇……作者：Chattopadhyay, D、Swingle, M.R、Salter, E.A、Wierzbicki, A、Honkanen, R.E. 存档日期：2015-05-19；发布日期：2016-04-27；最后修改日期：2023-09-27。实验方法：X射线衍射（分辨率1.23埃）。引用文献：《PPP家族丝氨酸/苏氨酸蛋白磷酸酶的晶体结构与诱变研究：阐明斑蝥素及新型去甲斑蝥素基PP5C抑制剂的选择性》，《Biochem. Pharmacol.》，第109卷，2016年

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2015-05-19