Patient characteristics.

PurposePersistent peritumoral brain edema (PTBE) following surgery of intracranial meningioma (IM) has recently been proposed to represent, in part, iatrogenic gliosis-like changes (IGCs). We aimed to estimate the frequency of IGCs after gross total resection (GTR) of IM, identify factors associated with IGCs, and assess their effect on surgical outcome.MethodsPatients with IM who underwent surgery between 2000 and 2020, presented with no preoperative PTBE on magnetic resonance imaging, and had at least one year of follow-up were retrospectively identified. Only patients without preoperative PTBE were included to ensure that postoperative hyperintense fluid-attenuated inversion recovery (FLAIR) changes were iatrogenic. Outcomes were evaluated based on postoperative symptoms and changes in Karnofsky Performance Status (KPS).ResultsA total of 255 meningioma patients without preoperative PTBE were identified. Of these, 133 (52.2%) showed postoperative IGCs on FLAIR imaging. IM location (p ConclusionIGCs are frequent following GTR of IM, and associate with IM location and volume. IGCs likely associate with impaired recovery following surgery and new-onset seizures.