Aging Mouse Brain Epigenetic

Aging is a major risk factor for neurodegenerative diseases, yet underlying epigenetic mechanisms remain unclear. Here, we generated a comprehensive single-nucleus cell atlas of brain aging across multiple brain regions, comprising 132,551 single-cell methylomes and 72,666 joint chromatin conformation-methylome nuclei. Integration with companion transcriptomic and chromatin accessibility data yielded a cross-modality taxonomy of 36 major cell types.

衰老是神经退行性疾病的主要风险因素，但其潜在的表观遗传（epigenetic）机制仍未阐明。本研究构建了覆盖多个脑区的衰老大脑综合单细胞核细胞图谱（single-nucleus cell atlas），包含132,551个单细胞甲基化组（single-cell methylome）与72,666个联合染色质构象-甲基化组细胞核（joint chromatin conformation-methylome nucleus）。通过整合配套的转录组（transcriptomic）与染色质可及性（chromatin accessibility）数据，本研究得到了涵盖36种主要细胞类型的多模态分类体系（cross-modality taxonomy）。