Single Cell mRNA Sequencing of Pca-associated CD14+CD11b+ macrophages

Purpose: Androgen receptor (AR) is a crucial modulator of prostate cancer (PCa) cells behaviour, and AR expression has been found in several stromal cells, including macrophages, however its role in these cells in largely unknown. In this study, we described the molecular mechanims and the functional implications of AR activation and blockade in macrophages in relation to PCa progression. Results: Analysis showed the transcriptomic landscape of PCa-associated macrophages Conclusions: Our study represents the first detailed analysis of AR molecular function in Pca-associated macrophages Overall design: Methods: Single cell mRNA sequencing has been performed on CD14+CD11b+ macrophages isolated from PCa biopsies of 3 untreated patients.