Zaied et al. supplementary data 1 - 10

Supplementary Data 1. STRING protein-protein interaction network in lung.Supplementary Data 2. PROPER protein-protein interaction network in lung.Supplementary Data 3. STRING protein-protein interaction network in whole blood.Supplementary Data 4. PROPER protein-protein interaction network in whole blood.Supplementary Data 5. Genes causal for asthma in the lung GRN identified using Mendelian randomisation (Wald ratio method).Supplementary Data 6. Genes causal for asthma in the Blood GRN identified using Mendelian randomisation (Wald ratio method and inverse variance weighted).Supplementary Data 7. significantly enriched (hypergeometric test, FDR≤0.05 and 500 sets of Monte Carlo simulations) asthma-trait interactions.Supplementary Data 8. curated gene-disease associations from DisGeNet for the identified level 0-4 genes (hypergeometric test, FDR≤0.05).Supplementary Data 9. Comorbidity analysis using health records of 2051661 hospitalized patients, 26781 of which had asthma (ICD10-AM code J459).Supplementary Data 10. list of level 0-4 genes (hypergeometric test, FDR≤0.05 and 500 sets of Monte Carlo simulation) that are part of the druggable genome and/or have known drug targets and/or have been causally associated with asthma through Mendelian Randomization.

附加数据 1：肺中 STRING 蛋白-蛋白相互作用网络。附加数据 2：肺中 PROPER 蛋白-蛋白相互作用网络。附加数据 3：全血中 STRING 蛋白-蛋白相互作用网络。附加数据 4：全血中 PROPER 蛋白-蛋白相互作用网络。附加数据 5：利用孟德尔随机化（Wald 比率法）识别的肺中哮喘因果基因的基因调节网络（GRN）。附加数据 6：利用孟德尔随机化（Wald 比率法和逆方差加权法）识别的血液中哮喘因果基因的基因调节网络（GRN）。附加数据 7：显著富集的哮喘性状相互作用（超几何检验，FDR≤0.05 和 500 组蒙特卡洛模拟）。附加数据 8：来自 DisGeNet 的关于识别的 0-4 级别基因的基因-疾病关联的精选数据（超几何检验，FDR≤0.05）。附加数据 9：利用 2051661 名住院患者的健康记录进行的共病分析，其中 26781 名患有哮喘（ICD10-AM 代码 J459）。附加数据 10：包含在可药基因组中或具有已知药物靶点，或通过孟德尔随机化因果关联哮喘的 0-4 级别基因列表（超几何检验，FDR≤0.05 和 500 组蒙特卡洛模拟）。