Pitaya-InspiredMetal-OrganicFrameworkNanozymefor MultimodalImaging-GuidedSynergisticCuproptosis, NanocatalyticTherapy,andPhotothermalTherapy
收藏中国科学院兰州化学物理研究所科学数据中心2026-01-13 更新2026-01-17 收录
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资源简介：
Natureoftenprovidesinvaluableinsightsintotechnologicalinnovationand
theconstructionofnanomaterials.Inspiredbythepitayafruit’sstrategyof
wrappingseedswithinitspulptoenhanceseedsurvival,aunique
nanocompositebasedonmetal-organicframework(MOF)-encapsulatedCuS
nanoparticles(NPs)isdeveloped.Thisdesigneffectivelyaddressesthe
challengeofshortretentiontimeaffordedbyCuSNPsfortherapeuticand
imagingpurposes.TheMOFactsasthe“pitayapulp”protectingtheinternal
CuSNPs(“pitayaseeds”),therebyincreasingtheirretentiontimeinvivo.This
systemexhibitstriple-enzyme-mimickingactivitiesandisproposedfor
applicationinphotoacousticandmagneticresonanceimaging-guided
therapies,includingchemodynamictherapy,photothermaltherapy,and
cuproptosis-relatedtherapy.Theexceptionalenzyme-mimickingactivitiesof
superoxidedismutase,catalase,andperoxidasenotonlyproduceoxygento
alleviatehypoxiabutalsogenerateareactiveoxygenspecies(ROS)stormfor
effectivetumordestruction.Bycombiningthesemultienzymaticproperties,
superiorphotothermalperformance,andCu-inducedcuproptosis,
nanozyme-treatedmiceexhibitedan84%inhibitionoftumor
growth—approximatelydoubletheeffectobservedinmicetreatedwithCuS
NPsalone.Thisstudypresentsasmartstrategyforintegratingimagingwith
therapeuticmodalities,achievingexceptionaloutcomesforprecise
imaging-guidedtumortherapy.
提供机构：
中国科学院兰州化学物理研究所科学数据中心
创建时间：
2026-01-13
