Isotope Effects and Mechanism of the Asymmetric BOROX Brønsted Acid Catalyzed Aziridination Reaction
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https://figshare.com/articles/dataset/Isotope_Effects_and_Mechanism_of_the_Asymmetric_BOROX_Br_nsted_Acid_Catalyzed_Aziridination_Reaction/2407546
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资源简介：
The mechanism of the chiral VANOL-BOROX
Brønsted acid catalyzed
aziridination reaction of imines and ethyldiazoacetate has been studied
using a combination of experimental kinetic isotope effects and theoretical
calculations. A stepwise mechanism where reversible formation of a
diazonium ion intermediate precedes rate-limiting ring closure to
form the cis-aziridine is implicated. A revised model
for the origin of enantio- and diastereoselectivity
is proposed based on relative energies of the ring-closing transition
structures.
创建时间：
2016-02-19
