five

Morphine PVT TRAPSeq

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NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE214560
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Using an oral self-administration paradigm, we have seen morphine increase neural activity in the Paraventricular Nucleus of the Thalamus (PVT). Morphine binds primarily to Mu Opioid Receptors (MORs), which are highly expressed in the PVT. Translating Ribosome Affinity Purification (TRAP)-Sequencing was conducted on PVT neurons that express MORs 11 days of 0.5mg/ml morphine dissolved in 0.2% saccharin in the drinking water. Just 0.2% saccharin in the drinking water was used as controls
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2023-06-23
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