Outdoor air pollution and the risk of asthma exacerbations in single lag0 and lag1 exposure patterns: a systematic review and meta-analysis

<b>Objective:</b> To synthesize evidence regarding the relationship between outdoor air pollution and risk of asthma exacerbations in single lag0 and lag1 exposure patterns. <b>Methods:</b> We performed a systematic literature search using PubMed, Embase, Cochrane Library, Web of Science, ClinicalTrials, China National Knowledge Internet, Chinese BioMedical, and Wanfang databases. Articles published until August 1, 2020 and the reference lists of the relevant articles were reviewed. Two authors independently evaluated the eligible articles and performed structured extraction of the relevant information. Pooled relative risks (RRs) and 95% confidence intervals (CIs) of lag0 and lag1 exposure patterns were estimated using random-effect models. <b>Results:</b> Eighty-four studies met the eligibility criteria and provided sufficient information for meta-analysis. Outdoor air pollutants were associated with increased risk of asthma exacerbations in both single lag0 and lag1 exposure patterns [lag0: RR (95% CI) (pollutants), 1.057(1.011, 1.103) (air quality index, AQI), 1.007 (1.005, 1.010) (particulate matter of diameter ≤ 2.5 μm, PM_2.5), 1.009 (1.005, 1.012) (particulate matter of diameter, PM₁₀), 1.010 (1.006, 1.014) (NO₂), 1.030 (1.011, 1.048) (CO), 1.005 (1.002, 1.009) (O₃); lag1:1.064(1.022, 1.106) (AQI), 1.005 (1.002, 1.008) (PM_2.5), 1.007 (1.004, 1.011) (PM₁₀), 1.008 (1.004, 1.012) (NO₂), 1.025 (1.007, 1.042) (CO), 1.010 (1.006, 1.013) (O₃)], except SO₂ [lag0: RR (95% CI), 1.004 (1.000, 1.007); lag1: RR (95% CI), 1.003 (0.999, 1.006)]. Subgroup analyses revealed stronger effects in children and asthma exacerbations associated with other events (including symptoms, lung function changes, and medication use). <b>Conclusion:</b> Outdoor air pollution increases the asthma exacerbation risk in single lag0 and lag1 exposure patterns. <b>Trial registration:</b> PROSPERO, CRD42020204097. https://www.crd.york.ac.uk/. Supplemental data for this article is available online at https://doi.org/10.1080/02770903.2021.2008429 .