Reciprocal regulation of phosphatidylcholine synthesis and H3K36 methylation programs metabolic adaptation II. Reciprocal regulation of phosphatidylcholine synthesis and H3K36 methylation programs metabolic adaptation II

Our findings demonstrated how phospholipid metabolism enabled metabolic transformation through an epigenetic modification, illuminating an underappreciated metabolic intersection for environmental adaptation in eukaryotic cells. Overall design: Saccharomyces cerevisiae (CEN.PK) mRNA profiles of WT/set2Δ/cho2Δ/cho2set2Δ/opi1Δ/opi1set2Δ at 1h in SL (minimal culture condition) switching from YPL(rich culture condition)