Purpose: The goal is to determine the requirement for Chl4 in association of cohesin with the centromere and pericentromere boundaries ChIP-Seq for wild type strains arrested in metaphase with and wit
Mammalian chromosomes are partitioned into topologically associating domains (TADs) by the loop-extrusion activity of cohesin that is blocked at specific DNA sites bound by CTCF. Chromosome structure
The relationship between cohesin-mediated chromatin looping and gene expression remains unclear. NIPBL and WAPL are two opposing regulators of cohesin activity; depletion of either is associated with
Structure of the Wpl1 protein Descriptor: WPL1 Authors: Chatterjee, A, Zakian, S, Hu, X.-W, Singleton, M.R. Deposit date: 2013-01-09 Release date: 2013-02-20 Last modified: 2024-05-08 Method: X-RAY DI
Mammary epithelium is composed by luminal and basal epithelial cells, which are adhere to the basement membrane (BM). To dissect how basal cell functions are regulated by BM laminin adhesion, we perf
