MutationAssessor r4 functional impact scores and multiple sequence alignments for human proteins

MutationAssessor Release 4 mutationassessor4_scores.tsv.zip Predicted functional impact score and functional impact for single amino acid subsitution mutations in human proteins. Columns: uniprotId: protein's UniProt accession hgvspShort: amino acid change and position F_score: functional impact score F_impact: categorical functional impact (neutral, low, medium, high) SV: UniProt sequence version MSA: multiple sequence alignment used to compute the scores (name-only) MAV: MutationAssessor version msa.zip Multiple sequence alignments in FASTA format, brotli-compressed. File name corresponds to the MSA column in the scores file. For each sequence, the Cluster field in the FASTA header indicates which subfamily the sequence belongs to after clustering by combinatorial entropy optimization (CEO). Citations: Yang Su, Xiang Li, Boris Reva, Yevgeniy Antipin, Ino de Bruijn, Nikolaus Schultz and Chris Sander (2025) Boris Reva, Yevgeniy Antipin and Chris Sander (2011) Predicting the functional impact of protein mutations: application to cancer genomics. Nucleic Acids Research, 39, e118. doi:10.1093/nar/gkr407