Immunization with meningococcal polysaccharide-tetanus toxoid conjugate induces polysaccharide-reactive T cells in mice.
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The polysaccharide used in this study is a homopolymer of Alpha-(2 → 8)-linked sialic acid. Two epitope-specific CD4+ T cell clones reacted with N. meningiditis serogroup C capsular polysachharide. The response requires the presence of and direct contact to APCs, but the APCs could be either syngeneic or allogenenic. Authors suggest the response is not MHC restricted.
提供机构:
IEDB
创建时间:
2004-01-01



