DNA modulates solvent isotope effects in a nanopore

Here we investigate the modulation of solvent isotope effects by the entry of DNA molecules into individual a-haemolysin nanopores. Solvent isotope effects in D2O versus H2O were enhanced (kH/kD 1.6) compared to the bulk (kH/kD 1.2), except when the pore was most blocked (kH/kD <= 1.1).