Crystal structure of D1228V c-MET bound by compound 16

Crystal structure of D1228V c-MET bound by compound 16 Descriptor: 1-[(1S)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl]-5-(1H-indazol-7-yl)pyrimidine-2,4-dione, Hepatocyte growth factor receptor, IODIDE ION Authors: Collie, G.W. Deposit date: 2023-04-26 Release date: 2023-07-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.206 Å) Cite: Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J.Med.Chem., 66, 2023化合物16结合的D1228V突变型c-MET晶体结构。描述项：1-[(1S)-1-[3-(1H-咪唑-4-基)苯基]乙基]-5-(1H-吲唑-7-基)嘧啶-2,4-二酮，肝细胞生长因子受体，碘离子。作者：Collie, G.W.。提交日期：2023-04-26。发布日期：2023-07-05。最后修改日期：2023-09-20。实验方法：X射线衍射（分辨率2.206埃）。引用文献：《首款ATP竞争性III型c-MET抑制剂的发现与优化》，J.Med.Chem., 66, 2023。