MarineNP: A Comprehensive and Locally Deployable Database of Marine Natural Products

Abstract Marine natural products (MNPs) are a vital source of chemical diversity for drug discovery and chemical biology. However, researchers are often hindered by fragmented data sources, proprietary access models, and a lack of tools that support large-scale computational analysis or work in offline environments. We present MarineNP, an open-access database designed to address these challenges. It offers three modes of access: (1) a powerful, web portal for interactive searching and data exportation; (2) complete database downloads in analysis-ready formats (SQL, CSV, RData); and (3) a cross-platform standalone application (Windows, macOS, Linux) that provides the full querying functionality in a fully offline environment. MarineNP improves existing resources by providing meticulously curated data, including taxonomic validation against the World Register of Marine Species (WoRMS) and the inclusion of geolocation information for source organisms. In total, MarineNP currently contains 74,507 unique marine natural products, 10,032 unique source organisms, and 2,653 distinct collection locations. Availability and Implementation: The MarineNP web server, all data downloads, and the standalone application are freely available to non-commercial users at https://marinenp.scicloud.eu/.