International Multi-Center ADHD Genetics Project

Acquiring DNA Samples All consent forms stipulate that the samples can only be used by researchers who have been approved by the National Institute of Mental Health (NIMH), National Institutes of Health. All consent forms, except those used at the Zürich site (N=141 subjects), explicitly indicate that the samples may be used by researchers from commercial enterprises seeking to benefit financially from the analysis of the samples. The Zürich consent does not prohibit such use. The Zürich consent form also included an "opt out" that allowed the subjects to indicate that they did not want their samples stored at the NIMH repository or used by researchers external to the project. No subjects enrolled in the project opted out. Consent groups and participant set ADHD (ADHD): 2758 (924 trios) ]]>
Demographic and personal dataDescription of Scoring AlgorithmsFlow Chart2003 PACS/Hypesecheme Algorithm for DSM-IV DiagnosesEMOTIONAL PATTERN, SECTION 1ACTIVITY LEVEL AND INATTENTIVE BEHAVIOUR, SECTION 2DISRUPTIVE BEHAVIOUR, SECTION 3COMORBID AND OTHER PROBLEMS, SECTION 4CONNERS' PARENTS RATING SCALE - Revised (L)Summary of IMAGE project recruitment protocolScoring the Informant-Rated Strengths and Difficulties QuestionnaireConners' Teacher Rating Scale - Revised (L)00Authorized access to GAIN Project Datasets: Application Instructions (retired document)Authorized access to GAIN Project Datasets: Application InstructionsADHD) genome-wide association scan has been pre-computed by NCBI with 924 trios composed of two parents and one child using a PERLEGEN 600k chip. The data were filtered using the following criteria:
Perlegen Quality score of 10 or higher.
SNP call rate and minor allele frequency (MAF).
The following 3-tiered filter was defined for SNP call rate and minor allele frequency (MAF) for SNPs in the Filtered release set.
Criteria for Passing a SNP:

0.01<=MAF<0.05 and call rate >= 99%.
0.05<=MAF<0.10 and call rate >= 97%.
0.10>=MAF and call rate >= 95%.

5 or more Mendelian errors are observed, data are not included.
Hardy-Weinberg Equilibrium test with p-value of higher than 0.000001.
After quality control, 438507 SNP markers and 877 trios were included in the transmission-disequilibrium test (TDT) using GAINQC software. The results have also been verified by plink, which is being developed by Shaun Purcell's group (Purcell et al., 2007).
]]> Proband diagnosis: combined subtype ADHD Children aged 6-17 years (inclusive) One or more sibling(s) in the same age range Both parents available to provide DNA sample or one parent available plus two or more siblings IQ above 70 Free of single-gene disorders known to be associated with ADHD (e.g. fragile-X, phenylketonuria, hypercalcaemia, thyroid hormone resistance) Free of neurological disease and damage (e.g. hemiplegia and other cerebral palsies, epilepsy, hydrocephalus, post- encephalitic syndromes, psychosis, sensorimotor handicaps) Living at home with at least one biological parent and one full sibling Not meeting criteria for autism or Asperger's syndrome ]]>