Vascular integrity is essential for maintaining tissue homeostasis

Purpose: analyze the transcriptomic differences in PBS and Riociguat treated whole lung lysate Methods: C57BL6 mice were given PBS or Riociguat treatment (i.g.). 24h later, homogenize lung and extract mRNA Results: Riociguat has merely effect on normal mice lung Overall design: C57BL6 mice were given PBS or Riociguat treatment (i.g.). 24h later, homogenize lung and extract mRNA. mRNA profiles of whole lung lysate were generated by sequencing.