Expression data from retinal pigment epithelium in pigmented and albino mouse embryos

In mammalian albinism, disrupted melanogenesis in the retinal pigment epithelium (RPE) is associated with fewer retinal ganglion cells (RGCs) projecting ipsilaterally to the brain, resulting in numerous abnormalities in the retina and visual pathway, especially binocular vision. To further understand the molecular link between disrupted RPE and a reduced ipsilateral RGC projection in albinism, we compared gene expression in the embryonic albino and pigmented mouse RPE. Embryonic day (E) 13.5 mouse RPE was detached from the eyes. Three biological replicates were analyzed. For each biological replicate (pigmented and albino), RPE tissues of three - four littermate embryos were pooled.