Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb

Inhibitory circuits in the mammalian olfactory bulb (OB) dynamically reformat olfactory information as it propagates from peripheral receptors to the downstream cortex. To gain mechanistic insight into how specific OB interneuron types support this sensory processing, we examine unitary synaptic interactions between excitatory mitral and tufted cells (MTCs), the OB projection neurons and a conserved population of anaxonic external plexiform layer interneurons (EPL-INs) using pair and quartet whole-cell recordings in acute mouse brain slices. Physiological, morphological, neurochemical, and synaptic analyses divide EPL-INs into distinct subtypes and reveal that parvalbumin-expressing fast-spiking EPL-INs (FSIs) perisomatically innervate MTCs with release-competent dendrites and synaptically detonate to mediate fast, short-latency recurrent and lateral inhibition. Sparse MTC synchronization supralinearly increases this high-fidelity inhibition, while sensory afferent activation combined w..., , , # Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb

[https://doi.org/10.5061/dryad.xd2547dr6](https://doi.org/10.5061/dryad.xd2547dr6)

\"NaN\" = \"Not a Number\", used to indicate entries for which no data is available (e.g., if a neuron's physiological data was successfully recorded but its morphology was not recovered in the post hoc staining process, then morphological measurements for that neuron are listed as \"NaN\").

### Fig 1

* Panels B-E
* Fig1B.txt, Fig1C.txt, Fig1D.txt, Fig1E.txt
* column 1: time (s): column 2: low current (pA); column 3: low voltage (mV); column 4: high current (pA); column 5: high voltage (mV)
* Panel F
* Fig1F.xls
* Panels H inset, J inset
* Fig1Hinset.txt, Fig1Jinset.txt
* column 1: time (ms): column 2: low current (pA); column 3: low voltage (mV); column 4: high current (pA); column 5: high voltage (mV)
* Panel K
* Fig1K.xls
* Panels L-O
* Fig1Lleft.txt, Fig1Lright.txt, Fig1Mleft.txt, Fig1Mright.txt...