Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV. Descriptor: 1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid, 1,2-ETHANEDIOL, APOLIPOPROTEIN(A), ... Authors: Sandmark, J, Althage, M, Andersson, G.M.K, Antonsson, T, Blaho, S, Bodin, C, Bostrom, J, Chen, Y, Dahlen, A, Eriksson, P.O, Evertsson, E, Fex, T, Fjellstrom, O, Gustafsson, D, Hallberg, C, Hicks, R, Jarkvist, E, Johansson, C, Kalies, I, Kang, D, Svalstedt Karlsson, B, Kartberg, F, Legnehed, A, Lindqvist, A.M, Martinsson, S.A, Moberg, A, Petersson, A.U, Ridderstrom, M, Thelin, A, Tigerstrom, A, Vinblad, J, Xu, B, Knecht, W. Deposit date: 2013-06-28 Release date: 2014-07-16 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2 Å) Cite: Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A) To be Published

针对载脂蛋白(a)（apo(a)）的kringle结构域（kringle）KIV-7、KIV-10及KV的选择性小分子抑制剂的鉴定。描述物：1,2,3,4-四氢异喹啉-6-羧酸、1,2-乙二醇、载脂蛋白(A)（APOLIPOPROTEIN(A)）等。作者：Sandmark, J、Althage, M、Andersson, G.M.K、Antonsson, T、Blaho, S、Bodin, C、Bostrom, J、Chen, Y、Dahlen, A、Eriksson, P.O、Evertsson, E、Fex, T、Fjellstrom, O、Gustafsson, D、Hallberg, C、Hicks, R、Jarkvist, E、Johansson, C、Kalies, I、Kang, D、Svalstedt Karlsson, B、Kartberg, F、Legnehed, A、Lindqvist, A.M、Martinsson, S.A、Moberg, A、Petersson, A.U、Ridderstrom, M、Thelin, A、Tigerstrom, A、Vinblad, J、Xu, B、Knecht, W。入库日期：2013年6月28日；发布日期：2014年7月16日；最后修改日期：2024年10月23日。检测方法：X射线衍射（分辨率2埃）。引用文献：《用于解析载脂蛋白(A)的kringle结构域KIV-7、KIV-10及KV的病理生理功能的小分子化合物》（待发表）