Transcriptomic Profiling of Mice with Klf5 Deletion in Context of Oncogenic Kras Expression

This study used Illumina RNA-sequencing to examine transcriptomic profile of mice with Klf5 knockout in context of oncogenic Kras expression. The study analyzed total RNA extracted from pancreas of mice 2 days after cerulein-induce pancreatitis. In addition, this study include 2 biological replicate of mice with each of the following genotypes: Ptf1aCreERTM, Ptf1aCreERTM;Klf5fl/fl, Ptf1aCerERTM;LSL-KrasG12D, and Ptf1aCreERTM;LSL-KrasG12D;Klf5fl/fl. Overall design: Transcriptomic profiling of pancreata from 2 Ptf1aCreERTM mice, 2 Ptf1aCreERTM;Klf5fl/fl mice, 2 Ptf1aCerERTM;LSL-KrasG12D mice, and 2 Ptf1aCreERTM;LSL-KrasG12D;Klf5fl/fl mice 2 days after cerulein-induced pancreatitis.