Dataset for Small Integrin Binding Ligand N-linked Glycoproteins, prostate-specific antigen and time to prostate cancer diagnosis.

Data are from a retrospective longitudinal case control study that was performed to determine the association of the SIBLINGs Dentin sialophosphoprotein (DSPP), bone sialoprotein (BSP), osteopontin (OPN) and prostate-specific antigen (PSA) with preclinical prostate cancer. Paired serum samples from 109 cancer-free Baltimore Longitudinal Study on Aging participants were divided into those that were either most distal or proximal to diagnosis (cases) or censoring (controls). DSPP, BSP, OPN, and PSA were measured by immunoassay and dichotomized into low or high based on their respective cut-off values. Associations of individual biomarkers and aggregated biomarkers with time to diagnosis or death, modeled as disease-free survival or overall survival, were assessed using Kaplan Meier to assess survival curves graphically and median survival estimates in distal or proximal sets separately. Cox proportional hazard survival hazard ratios were determined for individual and aggregated biomarkers in distal or proximal sets separately, Models were adjusted for age, BMI and hypertension and the significance of the hazard ratios was assessed by false discovery rate analysis.本研究数据源自一项回顾性纵向病例对照研究，旨在明确SIBLING家族的牙本质涎磷蛋白（Dentin sialophosphoprotein, DSPP）、骨涎蛋白（bone sialoprotein, BSP）、骨桥蛋白（osteopontin, OPN）与前列腺特异性抗原（prostate-specific antigen, PSA）和临床前期前列腺癌的关联。研究纳入109名无癌巴尔的摩衰老纵向研究参与者的配对血清样本，依据样本距确诊时间的远近分为病例组（确诊前最远或最近的样本）与删失对照组。采用免疫测定法检测DSPP、BSP、OPN与PSA的表达水平，并依据各自的截断值将其划分为低表达组与高表达组。以无病生存期或总生存期为建模终点，评估单个生物标志物与联合生物标志物与至诊断时间或死亡时间的关联；分别针对距确诊时间较远与较近的样本集，采用卡普兰-迈耶（Kaplan-Meier）法进行生存曲线的图形化分析与中位生存期估计。分别针对上述两类样本集，计算单个生物标志物与联合生物标志物的考克斯比例风险模型风险比；模型已针对年龄、体质量指数（Body Mass Index, BMI）与高血压进行校正，并通过错误发现率分析评估风险比的统计学显著性。