Cancer-Associated Mesothelial Cell-Derived ANGPTL4 and STC1 Promote the early steps of Ovarian Cancer metastasis

Ovarian Cancer preferentially metastasizes in association with mesothelial cell-lined surfaces.We sought to determine if mesothelial cells are required for OvCa metastasis and detect alterations in mesothelial cell gene expression upon interaction with OvCa cells. To evaluate the OvCa-induced transcriptome changes in mesothelial cells, primary human mesothelial cells from 10 patients were treated with OvCa conditioned media or ascites and RNAseq analysis was performed. Comparative Gene expression profiling of RNAseq data for Human primary mesothelial cells treated with ovarian cancer cell conditioned media, ascites or control media.