Alignment of the first five E. tenella homologue kinase proteins to the mouse p38α MAPK.

* AA phosphorylated.The first five E. tenella homologue kinase proteins with the lowest e values (Table 1) are aligned to the mouse p38α MAPK. The main motifs of subdomains of the eukaryotic protein kinase catalytic domain of the mammalian p38α MAPK are aligned to the five parasite kinases. In bold, the common amino acids are shown; in italic are amino acids found at a high frequency among proteins analyzed. The amino acids K53 and D168 (numbered in Mus musculus) are both required for catalytic activity. The amino acids T180 and Y182 (numbered in Mus musculus) are exposed at the surface of the inactivated p38α MAPK and phosphorylated by MAP kinases kinases leading to the activation of the p38α MAPK.Alignment of the first five E. tenella homologue kinase proteins to the mouse p38α MAPK.