TOPICAL ANTIBIOTICS LIMIT DEPIGMENTATION IN A MOUSE MODEL OF VITILIGO

Antibiotic ointments were topically applied to vitiligo-prone, pmel-1 mice, evaluating the consequences of short-term antibiotic treatment on the kinetics of depigmentation. Bacitracin, Neosporin, or Vaseline were applied to one denuded flank, while the contralateral flank was treated with Vaseline in all mice. Ventral depigmentation was quantified weekly. We found that topical Neosporin treatment significantly reduced depigmentation and exhibited effects beyond the treated area, while Bacitracin ointment had no effect. Our study highlights the therapeutic potential of short-term antibiotic applications to limit depigmentation vitiligo.将抗生素软膏局部外用至易患白癜风（vitiligo）的pmel-1小鼠（pmel-1 mice），以评估短期抗生素治疗对色素脱失（depigmentation）动力学的影响。为每只小鼠的单侧脱毛侧腹涂抹杆菌肽（Bacitracin）、新霉素软膏（Neosporin）或凡士林（Vaseline），所有小鼠的对侧侧腹均以凡士林处理。每周对腹侧色素脱失情况进行定量评估。研究结果显示，局部外用新霉素软膏可显著减轻色素脱失，且其作用范围可超出给药区域，而杆菌肽软膏则无此类效果。本研究揭示了短期外用抗生素软膏用于限制白癜风色素脱失的治疗潜力。