Additional file 1 of Tropomyosin 1 genetically constrains in vitro hematopoiesis

Additional file 1:Table S1. The 860 chromatin feature tracks included in our LASSO analysis. These data were obtained from ENCODE [68], ChromHMM [81], and analyses of primary human MK cells [26]. Table S2. Chromatin features and coefficients comprising our penalized regression-based platelet scoring model. Coefficients for background parameters are included at the bottom of this list, but were not included in subsequent genome-wide SNP scoring. Table S3. Gene Ontology pathways that were significantly enriched in the top 1% of SNPs, as defined by platelet model scores. Presented pathways had false discovery rate (FDR) 0.7), scored in the top 5% by both our platelet trait and red cell models, overlap canonical or near-canonical GATA binding sites, and are eQTLs for at least 1 gene [41] (GTEx V7). Associated GWAVA [17] scores are present, if available. SNP rsIDs and locations refer to hg19 genome. Table S11. Semi-quantitative RT-PCR primers used in this study.