Pattern of vascular leakage in the brains of Naglu mice at different stages of disease.

Key: Cx – cerebral cortex, Hip – hippocampus, Cb – cerebellum, Md – medulla, MB – midbrain, OB – olfactory bulb, PS – pons, ST – striatum, TH – thalamus, EB – Evans Blue, Alb – albumin, -- - no leak, + - moderate leak (near abluminal side of the capillaries), ++ - significant leak (at a distance from the capillaries). Note: no vascular leakage was determined in examined brain blood vessels from control mice at 3, 6 or 10–12 months of age.