AMYPAD PNHS - Integrated dataset (Harmonized and Derived) v202306

Description:

The Amyloid Imaging to Prevent Alzheimer’s Disease (AMYPAD) Prognostic and Natural History Study (PNHS) is an open-label, prospective, multicentre, cohort study linked to a variety of European Parent Cohorts.

AMYPAD PNHS aims to improve disease modelling efforts and individualized risk stratification within the context of Alzheimer's disease, by the additional collection of amyloid burden, measured by positron emission tomography (PET) imaging.

The current version of the AMYPAD PNHS dataset integrates information from 10 Parent Cohorts: ALFA+, AMYPAD DPMS, DELCODE, EMIF-AD (60++), EMIF-AD (90+), EPAD LCS, FACEHBI, FPACK, Microbiota, and UCL-2010-412. This dataset includes a total of 3368 participants. Of them, 1620 underwent a baseline amyloid PET that includes the visual read and the Centiloid quantification (1476 subjects), among other metrics. Moreover, 888 participants have (at least) one follow-up PET scan, 763 of them with Centiloid quantification. The participant's clinical outcomes (e.g., cognition), disease (imaging) biomarkers, risk factors (e.g., genetics and environmental), and other relevant variables are included in the dataset.

Data Access Request:

Those researchers interested in using the integrated AMYPAD PNHS dataset can request access to the imaging, clinical, and biomarker data for scientific research investigation and/or educational activities. The application can be performed via the FAIR Data Service of the Alzheimer’s Disease Data Initiative (ADDI).

Direct link: https://fair.addi.ad-datainitiative.org/#/data/datasets/amypad_pnhs__harmonised_and_derived__v202306

Further details can be found in the AMYPAD PNHS Data Access Request documentation.

Note:

This version of the dataset includes only the 'harmonised' and 'derived' set of variables (further details can be found in the AMYPAD PNHS Data Access Request documentation.