Staphylococcus aureus strain:N315 Raw sequence reads. Staphylococcus aureus strain:N315

The T-box is a structurally conserved riboswitch-like gene regulator in the 5 prime-untranslated region (UTR) of numerous essential genes of Gram-positive bacteria.We previously demonstrated that a small molecule drug PKZ18 targets the T-box mechanism to inhibit bacterial growth. RNA sequencing shows that the analog PKZ18-22 affects expression of most T-box controlled genes, but not other 5 prime UTR regulated genes in Staphylococcus aureus (MRSA).