Nonracemizable Isocyanoacetates for Multicomponent Reactions
收藏NIAID Data Ecosystem2026-03-06 收录
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Chiral ortho esters of α-isocyano acids were synthesized from commercially available Cbz-protected α-amino acids. These compounds are stable toward racemization in the Ugi 4CC in contrast to known esters of α-isocyano acids. Applying them in Ugi 4CC with subsequent deprotection gives access to dipeptides with preserved configuration at the C-terminal amino acid.
创建时间:
2009-01-16



