Amino acid residue mapping for nuclear receptors considered in this study.

H stands for helices. ‘Alignment residue’ is the generic numbering used in this study (S1 Fig). The class specific residues are specified by I and II for class I and class II NRs, respectively, with boxes colored in blue and green, respectively, or in cyan for residues common to class I and class II, together with the corresponding residue number [17]. The H7 column with yellow boxes refers to residues of the π-turn, further highlighting the differential conservation of the p-turn.