Multi-omics analysis of environment-host-skin microbial interactions of Tibetan sheep in response to extreme high-altitude environments

In this study, Tibetan sheep lived at three altitudes (4500 m, 3500 m, 2500 m) were used for proteomic and metabolomic studies of the skin and two altitudes (4500 m and 2500 m) were used for macro-genomic and metabolomic studies of the skin microbes, as well as joint multi-omics analyses, to gain insights into the extreme environments on the skin and the skin microbes and their metabolites.