The Influence of I47A Mutation on Reduced Susceptibility to the Protease Inhibitor Lopinavir

The Influence of I47A Mutation on Reduced Susceptibility to the Protease Inhibitor Lopinavir Descriptor: BETA-MERCAPTOETHANOL, HIV-1 Protease, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE Authors: Brynda, J, Klara, S, Kozisek, M, Lepsik, M, Machala, L, Konvalinka, J. Deposit date: 2007-06-28 Release date: 2008-07-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir. Protein Sci., 17, 2008

I47A突变对降低对蛋白酶抑制剂洛匹那韦（Lopinavir）易感性的影响
描述符：β-巯基乙醇（BETA-MERCAPTOETHANOL）、HIV-1蛋白酶（HIV-1 Protease）、N-{1-苄基-4-[2-(2,6-二甲基苯氧基)-乙酰氨基]-3-羟基-5-苯基戊基}-3-甲基-2-(2-氧代四氢嘧啶-1-基)丁酰胺
作者：Brynda, J、Klara, S、Kozisek, M、Lepsik, M、Machala, L、Konvalinka, J
存档日期：2007-06-28
发布日期：2008-07-01
最后修改日期：2023-11-01
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.31埃（Å）
引用文献：《I47A突变降低对HIV蛋白酶抑制剂洛匹那韦易感性的酶学与结构分析》，《Protein Sci.》（《蛋白质科学》），第17卷，2008年