Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-N-hydroxy-4-methylpentanamide

Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-N-hydroxy-4-methylpentanamide Descriptor: (2S)-4-methyl-N-[(1R)-2-(oxidanylamino)-2-oxidanylidene-1-phenyl-ethyl]-2-[(phenylmethyl)carbamoylamino]pentanamide, GLYCEROL, M1 family aminopeptidase, ... Authors: Marapaka, A.K, Zhang, Y, Addlagatta, A. Deposit date: 2017-05-12 Release date: 2018-06-20 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization Chin.Chem.Lett., 33, 2022

恶性疟原虫（Plasmodium falciparum）氨肽酶N与(S)-2-((2S,3R)-3-氨基-2-羟基-4-苯基丁酰胺基)-N-羟基-4-甲基戊酰胺形成复合物的晶体结构。描述符：(2S)-4-甲基-N-[(1R)-2-(羟氨基)-2-氧代-1-苯基乙基]-2-[(苄基)氨基甲酰氨基]戊酰胺、甘油、M1家族氨肽酶……作者：Marapaka A.K.、Zhang Y.、Addlagatta A.。存档日期：2017-05-12；发布日期：2018-06-20；最后修改日期：2023-11-22。实验方法：X射线衍射（1.96 Å）。引用文献：《肽模拟羟肟酸类PfA-M1与PfA-M17双重抑制剂的开发：生物评价与共结晶结构表征》，《中国化学快报》（Chin.Chem.Lett.），33卷，2022年。