Sequential Catalysis of Phosphine Oxide for Stereoselective Synthesis of Stereopentads

An efficient method
for accessing enantiomerically pure stereopentads
via a catalytic asymmetric sequential aldol reaction has been developed
for the first time. The enantioselective sequential aldol reaction
produces a wide range of chiral stereopentad precursors in good yields
with excellent enantioselectivities. The key to success is the use
of the sequential catalytic system involving a chiral phosphine oxide
catalyst and trichlorosilyl triflate.