Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide

Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide Descriptor: 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... Authors: Miyahara, S, Chong, K.T, Suzuki, T. Deposit date: 2019-12-19 Release date: 2020-12-23 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.55 Å) Cite: TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published

核糖核苷酸还原酶（Ribonucleotide reductase）R1亚基（RRM1）与5-氯-N-((1S,2R)-2-(6-氟-2,3-二甲基苯基)-1-(5-氧代-4,5-二氢-1,3,4-噁二唑-2-基)丙基)-4-甲基-3,4-二氢-2H-苯并[b][1,4]噁嗪-8-磺酰胺形成复合物的晶体结构
描述物：5-氯-N-((1S,2R)-2-(6-氟-2,3-二甲基苯基)-1-(5-氧代-4,5-二氢-1,3,4-噁二唑-2-基)丙基)-4-甲基-3,4-二氢-2H-苯并[b][1,4]噁嗪-8-磺酰胺、镁离子、核糖核苷二磷酸还原酶大亚基（Ribonucleoside-diphosphate reductase large subunit）……
作者：Miyahara S、Chong K.T、Suzuki T
沉积日期：2019-12-19
发布日期：2020-12-23
最后修改日期：2023-11-22
解析方法：X射线衍射（分辨率2.55埃）
引用文献：TAS1553——一种新型小分子核糖核苷酸还原酶（Ribonucleotide reductase, RNR）亚基相互作用抑制剂，具有显著抗肿瘤活性（待发表）