3d Structure of the Human Hippocampus by holo-tomography: Alzheimer Disease vs Control

This study leverages X-ray phase-contrast tomography for detailed analysis of neurodegenerative diseases focusing on the 3D visualization and quantification of neuropathological features within fixed human postmortem tissue. X-ray phase-contrast tomography with synchrotron radiation offers micrometer and even sub-micron resolution, enabling us to examine intra- and extraneuronal aggregates and inclusions such as Lewy bodies, granulovacuolar degeneration, Hirano bodies, neurofibrillary tangles, β-amyloid plaques and vascular amyloid deposits in three dimensions (3D).