Variables, settings, and sources of parameters in the model.

1This infectivity is calibrated such that one index case creates on average 1.3 secondary cases in a population of 1000 healthy susceptibles and conforms to Blower (2004) [36].
2Fitness is a multiplier that determines both the probability of transmission to susceptibles and progression from latent to active in MDR cases.
3DNA fingerprinting of active TB cases shows that it is rare that patients are infected with multiple strains simultaneously [22] making it plausible that latent infection offers immune protection. Evaluating the potential importance of this phenomenon is one of the key contributions of this model.