Additional file 2 of Phenome-wide analyses identify an association between the parent-of-origin effects dependent methylome and the rate of aging in humans

Additional file 2: Table S1. Discovery and replication results by MOA and CpG outcome models for the 115 associations identified in discovery dataset. Table S2. Discovery and replication results by MOA models for the 92 high-confidence associations between POE-CpGs and phenotypes. Table S3. Conditional analyses results for POE-CpGs’ association with parental smoking exposure. Table S4. Enrichment test results for POE-CpGs associated with specific phenotype in functional regions. Table S5. Per phenotype resultsfor comparisons between methylation association signals from POE regions versus non-POE regions. Table S6. Comparisons between results from sensitivity models using SIMD as covariates and results from the raw models. Table S7. Information for matched modules between discovery and replication datasets. Table S8. Information of constituting CpGs of POE co-methylation modules. Table S9. Significant and replicated associations between POE co-methylation module PCs and phenotypes. Table S10. Comparisons of the distribution of module connectivityof atypical POE module 3 across different age groups by Wilcox test. Table S11. Comparisons of variation of module connectivityof atypical POE module 3 across different age groups by Levene test. Table S12. The degree and closeness centrality of constituting GpGs of atypical POE module 3 in sharp increasing cluster. Table S13. Comparisons of connectivity radiated from each constituting CpG in aypical POE module 3 in the sharply increasing cluster between youngestand oldestgroups. Table S14. Annotations for the five hub CpGs of the atypical POE module 3. Table S15. The loading of each constituting POE-CpG in the first PC of atypical POE module 3. Table S16. Significant associations between POE-CpGs and chronological age. Table S17. Comparisons of Shannon entropy in CpGs belonging to different groups. Table S18. The correlations between methylation Shannon entropy and age. Table S19. Phenotypic information. Table S20. Number of samplesin each age group.