Stereoselective Synthesis of β‑Lactam-triflones under Catalyst-Free Conditions
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https://figshare.com/articles/dataset/Stereoselective_Synthesis_of_Lactam_triflones_under_Catalyst_Free_Conditions/2106922
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资源简介：
The
first example of the synthesis of β-lactam-triflones is described.
Treatment of 2-diazo-1-aryl-2-(trifluoromethylsulfonyl)ethanones 1cf with imines 2 under
catalyst-free heating conditions provides pharmaceutically attractive
multisubstituted β-lactam-triflones 3 in good to
high yields with regio- and diastereoselectivities. A successive
Wolff rearrangement and Staudinger [2 + 2] cycloaddition reaction
are key elements for the success of this transformation.
创建时间：
2016-02-12
