Crystal Structure of Porphyromonas gingivalis Sialidase (PG_0352) D219A mutant bound to 6'-Sialyllactose (only Neu5Ac visible)
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Crystal Structure of Porphyromonas gingivalis Sialidase (PG_0352) D219A mutant bound to 6'-Sialyllactose (only Neu5Ac visible) Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, N-acetyl-alpha-neuraminic acid, ... Authors: Clark, N.D, Malkowski, M.G. Deposit date: 2023-06-05 Release date: 2023-10-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.41 Å) Cite: Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors. Plos Pathog., 19, 2023
牙龈卟啉单胞菌（Porphyromonas gingivalis）唾液酸酶（PG_0352）D219A突变体结合6'-唾液酸乳糖（仅可观测到N-乙酰神经氨酸（Neu5Ac））的晶体结构 配体描述：1,2-乙二醇、二(羟乙基)醚、N-乙酰-α-神经氨酸，…… 作者：Clark, N.D.、Malkowski, M.G. 沉积日期：2023-06-05 发布日期：2023-10-04 最后修改时间：2023-10-11 实验方法：X射线衍射（1.41埃） 引用文献：功能与结构分析显示，双结构域唾液酸酶可通过对补体因子进行去唾液酸化作用，使细菌逃避补体杀伤。《PLOS 病原体》（Plos Pathog.），19卷，2023年
