Source data for unprocessed immuno-blots in manuscript CELL-STEM-CELL-D-19-00624
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In this study, we investigated the role of histone crotonylation in regulation of linage specification of human embryonic stem cells. We showed that histone crotonylation is crucial for meso/endoderm differentiation by enhancing mesodermal and endodermal gene expression. Consistently, chemical enhancement of histone crotonylation promotes endoderm differentiation of hESCs, whereas deletion of crotonyl-CoA producing enzymes reduces histone crotonylation and impairs meso/endoderm differentiation in vitro and in vivo.
创建时间：
2021-01-06
