XIST modulates mammary stem cell homeostasis and tumor fate
收藏NIAID Data Ecosystem2026-03-12 收录
官方服务:
资源简介:
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
应用场景:
创建时间:
2021-01-04
相关数据集
Tumor induction by a transformation-defective polyoma virus mutant blocked in signaling through Shc
Transformation of cells in culture by polyoma virus requires integration of signals downstream of middle T–Shc and middle T-phosphatidylinositol 3-kinase interactions, but the same is not true for ind
PubMed Central1997-07-22 更新40
XIST modulates mammary stem cell homeostasis and tumor fate [WGS]
Disruption of XIST expression in mammary epithelial cells leads to chromatin changes on the inactive X chromosome, transcriptional reactivation of X-linked genes, and defective luminal differentiation
NIAID Data Ecosystem20
The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2
The Mdm2 oncoprotein forms a complex with the p53 tumor suppressor protein and inhibits p53-mediated regulation of heterologous gene expression. Recently, Mdm2 has been found to bind several other pro
PubMed Central1996-11-26 更新10
Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss
Cyclin D1 is a regulatory subunit of cyclin-Dependent Kinases 4 and 6 (CDK4/6) and regulates progression from G1 to S phase of the cell cycle. Dysregulated cyclin D1-CDK4/6 contributes to tumor develo
NIAID Data Ecosystem30
Transcriptome changes following loss of Apc in the intestine. Mus musculus
Nearly all colorectal cancers have dysregulated Wnt signalling, predominantly through the mutation of the Apc (Adenomatous Polyposis Coli) gene. Therefore it is of vital importance to elucidate the ke
NIAID Data Ecosystem10



