Metabolic gene transcriptional responses in Hepa1c1c7 cells

This is a laboratory study of oil chemicals that induce changes in gene expression in the Hepa1c1c2 cell line. Dose response profiles, as assessed by gene expression, were determined for selected polycyclic aromatic hydrocarbons (PAHs) found in oil. These gene expression dose responses were compared across several marker genes (CYP1A1, 1B1, 1A2, NQO1, etc.,) to determine relationships to cytotoxicity of PAHs.