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Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

ChEBI2013-11-08 更新2026-07-21 收录

表观遗传调控

疾病遗传学

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-51312 数据链接链接失效反馈

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Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

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创建时间：

2013-11-08

肝病相关单核细胞功能障碍

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BACKGROUND/ AIMS: Severe forms of alcoholic liver disease are associated with increased susceptibility to infections largely due to immune dysfunction. In this study, we analyze the phenotypic, molecu

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Transcriptional Dynamics of Skeletal Muscle in Obesity (PRJCA023478)

肥胖相关转录组学

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Skeletal muscle is a metabolically active organ, but it remains largely unexplored in obesity. Here, we used diet-induced mice as obesity model to investigate the effect of obesity on muscle transcrip

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ARID1B regulates BCL11B-mediated non-canonical Activin signaling to maintain mesenchymal stem cell homeostasis in the mouse incisor [scRNA-seq]

干细胞稳态

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ARID1B is a epigenetic regulator. We used the scRNA sequencing to analysis the role of ARID1B in regulating mouse incisor tissue homeostasis. Single-cell transcriptomes were obtained from the digested

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mRNA profiling of Pontin WT and RA under glucose starvation

表观遗传调控

葡萄糖饥饿应激

To determine which genes are affected by methylated Pontin, we performed RNA-sequencing (RNA-seq) in Pontin WT and RA MEFs after glucose starvation. Overall design: mRNA expression profiles of Pontin

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DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation [RNA-seq]

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甲基化反应机制

DNA methylation at the 5-position of cytosine (5mC) is a crucial epigenetic mark in regulating biological processes including gene silencing, gene imprinting, and X chromosome inactivation. It has lon

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Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

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