NPAS4 binds CDK5 gene promoter

Based on studies in mouse, NPAS4 binds the promoter of the CDK5 gene in differentiating neurons (Yun et al. 2013). The promoter region of the mouse Cdk5 gene that Npas4 binds to is conserved in the human CDK5 gene promoter. It is uncertain whether NPAS4 heterodimerized with ARNT, ARNT2 or ARNTL binds to the CDK5 gene promoter. Therefore, all three complexes (NPAS4:ARNT, NPAS4:ARNT2 and NPAS4:ARNTL) are shown as candidates. Binding of Arnt and Arnt2 to the promoter of Cdk5 gene in primary cultures of rat neurons was detected but binding of Npas4 to the Cdk5 gene promoter was not reported (Brigidi et al. 2019).

基于对小鼠的研究，NPAS4结合了分化神经元中的CDK5基因启动子（Yun等人，2013年）。小鼠CDK5基因中Npas4结合的启动子区域在人类CDK5基因启动子中得以保守。关于NPAS4是否与ARNT、ARNT2或ARNTL形成异源二聚体并结合CDK5基因启动子尚存疑虑。因此，所有三种复合体（NPAS4:ARNT、NPAS4:ARNT2和NPAS4:ARNTL）均被列为候选对象。在鼠神经元原代培养中检测到了Arnt和Arnt2与Cdk5基因启动子的结合，但Npas4与Cdk5基因启动子的结合尚未见报道（Brigidi等人，2019年）。