Summary of the lymphoid pathology in EμEBER1 lines.

The number of transgenic positive animals which have either developed lymphoma or shown signs of lymphoid expansion, out of the total number of animals examined in the different age categories are shown (number with lymphoid pathology (bold: of which were neoplastic)/total number of mice in the category). The majority of negative mice examined in the 19-24 months category were taken at 23/24 months at the end of study. Generally mice examined under 1 year old were taken in cohort groups (without phenotypic selection) for particular studies (eg. expression analysis). The percentage of mice with tumour-expansion compared to no tumour is indicated for each line. The P values were calculated from a chi squared (P χ2) test. To avoid bias due to the large number of negative sibling control mice taken under the age 10 months, largely phenotype free, the percentage of mice with lymphoid expansion and chi squared tests are also shown for the older age groups alone (>10≤24 months and >19≤24 months, in the panels below).