Enhancement of proliferation and degranulation by blockade of wPD-L1 or wPD-L2 with specific antibodies.

PBMCs from naïve, acutely and chronically infected woodchucks were stimulated with WHcAg or WHcAg-derived peptides in the presence or absence of anti-wPD-L1 or anti-wPD-L2 antibody. The proliferation and degranulation of woodchuck PBMCs were determined. The number of woodchucks which showed an enhanced proliferation or degranulation is given in the table.*Samples were anlayzed by Pearson chi-square/Fisher's exact test, comparing the effect of control antibody and anti-wPD-L1 antibody (P = 0.015).